Increased Tumoral Microenvironmental pH Improves Cytotoxic Effect of Pharmacologic Ascorbic Acid in Castration-Resistant Prostate Cancer Cells

BACKGROUND: The anticancer potential of pharmacologic ascorbic acid (AA) has been detected in a number of cancer cells. However, in vivo study suggested a strongly reduced cytotoxic activity of AA. It was known that pH could be a critical influencing factor for multiple anticancer treatments. In thi...

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Detalles Bibliográficos
Autores principales: Li, Zhoulei, He, Peng, Luo, Ganhua, Shi, Xinchong, Yuan, Gang, Zhang, Bing, Seidl, Christof, Gewies, Andreas, Wang, Yue, Zou, Yuan, Long, Yali, Yue, Dianchao, Zhang, Xiangsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538777/
https://www.ncbi.nlm.nih.gov/pubmed/33071784
http://dx.doi.org/10.3389/fphar.2020.570939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538777/
https://www.ncbi.nlm.nih.gov/pubmed/33071784
http://dx.doi.org/10.3389/fphar.2020.570939

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