Slow-binding reversible inhibitor of acetylcholinesterase with long-lasting action for prophylaxis of organophosphate poisoning

Organophosphorus (OP) compounds represent a serious health hazard worldwide. The dominant mechanism of their action results from covalent inhibition of acetylcholinesterase (AChE). Standard therapy of acute OP poisoning is partially effective. However, prophylactic administration of reversible or ps...

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Detalles Bibliográficos
Autores principales: Lenina, Oksana A., Zueva, Irina V., Zobov, Vladimir V., Semenov, Vyacheslav E., Masson, Patrick, Petrov, Konstantin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538863/
https://www.ncbi.nlm.nih.gov/pubmed/33024231
http://dx.doi.org/10.1038/s41598-020-73822-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538863/
https://www.ncbi.nlm.nih.gov/pubmed/33024231
http://dx.doi.org/10.1038/s41598-020-73822-6

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