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Slow-binding reversible inhibitor of acetylcholinesterase with long-lasting action for prophylaxis of organophosphate poisoning
Organophosphorus (OP) compounds represent a serious health hazard worldwide. The dominant mechanism of their action results from covalent inhibition of acetylcholinesterase (AChE). Standard therapy of acute OP poisoning is partially effective. However, prophylactic administration of reversible or ps...
Autores principales: | Lenina, Oksana A., Zueva, Irina V., Zobov, Vladimir V., Semenov, Vyacheslav E., Masson, Patrick, Petrov, Konstantin A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538863/ https://www.ncbi.nlm.nih.gov/pubmed/33024231 http://dx.doi.org/10.1038/s41598-020-73822-6 |
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