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Simulations on the dual effects of flavonoids as suppressors of Aβ42 fibrillogenesis and destabilizers of mature fibrils

Structural studies of the aggregation inhibition of the amyloid-β peptide (Aβ) by different natural compounds are of the utmost importance due to their great potential as neuroprotective and therapeutic agents for Alzheimer’s disease. We provided the simulation of molecular dynamics for two differen...

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Detalles Bibliográficos
Autores principales: Gargari, Sahar Andarzi, Barzegar, Abolfazl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538952/
https://www.ncbi.nlm.nih.gov/pubmed/33024142
http://dx.doi.org/10.1038/s41598-020-72734-9