Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29

VARP and TBC1D5 are accessory/regulatory proteins of retromer-mediated retrograde trafficking from endosomes. Using an NMR/X-ray approach, we determined the structure of the complex between retromer subunit VPS29 and a 12 residue, four-cysteine/Zn(++) microdomain, which we term a Zn-fingernail, two...

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Detalles Bibliográficos
Autores principales: Crawley-Snowdon, Harriet, Yang, Ji-Chun, Zaccai, Nathan R., Davis, Luther J., Wartosch, Lena, Herman, Emily K., Bright, Nicholas A., Swarbrick, James S., Collins, Brett M., Jackson, Lauren P., Seaman, Matthew N. J., Luzio, J. Paul, Dacks, Joel B., Neuhaus, David, Owen, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539009/
https://www.ncbi.nlm.nih.gov/pubmed/33024112
http://dx.doi.org/10.1038/s41467-020-18773-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539009/
https://www.ncbi.nlm.nih.gov/pubmed/33024112
http://dx.doi.org/10.1038/s41467-020-18773-2

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