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Glufosinate constrains synchronous and metachronous metastasis by promoting anti‐tumor macrophages
Glutamine synthetase (GS) generates glutamine from glutamate and controls the release of inflammatory mediators. In macrophages, GS activity, driven by IL10, associates to the acquisition of M2‐like functions. Conditional deletion of GS in macrophages inhibits metastasis by boosting the formation of...
Autores principales: | Menga, Alessio, Serra, Marina, Todisco, Simona, Riera‐Domingo, Carla, Ammarah, Ummi, Ehling, Manuel, Palmieri, Erika M, Di Noia, Maria Antonietta, Gissi, Rosanna, Favia, Maria, Pierri, Ciro L, Porporato, Paolo E, Castegna, Alessandra, Mazzone, Massimiliano |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539200/ https://www.ncbi.nlm.nih.gov/pubmed/32885605 http://dx.doi.org/10.15252/emmm.201911210 |
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