Striatal infusion of cholesterol promotes dose‐dependent behavioral benefits and exerts disease‐modifying effects in Huntington's disease mice

A variety of pathophysiological mechanisms are implicated in Huntington's disease (HD). Among them, reduced cholesterol biosynthesis has been detected in the HD mouse brain from pre‐symptomatic stages, leading to diminished cholesterol synthesis, particularly in the striatum. In addition, syste...

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Detalles Bibliográficos
Autores principales: Birolini, Giulia, Valenza, Marta, Di Paolo, Eleonora, Vezzoli, Elena, Talpo, Francesca, Maniezzi, Claudia, Caccia, Claudio, Leoni, Valerio, Taroni, Franco, Bocchi, Vittoria D, Conforti, Paola, Sogne, Elisa, Petricca, Lara, Cariulo, Cristina, Verani, Margherita, Caricasole, Andrea, Falqui, Andrea, Biella, Gerardo, Cattaneo, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539329/
https://www.ncbi.nlm.nih.gov/pubmed/32959531
http://dx.doi.org/10.15252/emmm.202012519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539329/
https://www.ncbi.nlm.nih.gov/pubmed/32959531
http://dx.doi.org/10.15252/emmm.202012519

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