Overexpression of UBQLN1 reduces neuropathology in the P497S UBQLN2 mouse model of ALS/FTD

Missense mutations in UBQLN2 cause X-linked dominant inheritance of amyotrophic lateral sclerosis with frontotemporal dementia (ALS/FTD). UBQLN2 belongs to a family of four highly homologous proteins expressed in humans that play diverse roles in maintaining proteostasis, but whether one isoform can...

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Detalles Bibliográficos
Autores principales: Wang, Shaoteng, Tatman, Micaela, Monteiro, Mervyn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539388/
https://www.ncbi.nlm.nih.gov/pubmed/33028421
http://dx.doi.org/10.1186/s40478-020-01039-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539388/
https://www.ncbi.nlm.nih.gov/pubmed/33028421
http://dx.doi.org/10.1186/s40478-020-01039-9

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