A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells

A novel alkynyl phosphane gold(I) complex (trimethylphosphane)(3‐(1,3‐dimethylxanthine‐7‐yl)prop‐1‐yn‐1‐yl)gold(I) 1 displayed mutiple biological activites including selective proliferation inhibitory, anti‐metastatic, and anti‐angiogenic effects. The complex also induced effects related to aneuploi...

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Autores principales: Zhang, Jing‐Jing, Abu el Maaty, Mohamed A., Hoffmeister, Henrik, Schmidt, Claudia, Muenzner, Julienne K., Schobert, Rainer, Wölfl, Stefan, Ott, Ingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540060/
https://www.ncbi.nlm.nih.gov/pubmed/32529715
http://dx.doi.org/10.1002/anie.202006212
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author Zhang, Jing‐Jing
Abu el Maaty, Mohamed A.
Hoffmeister, Henrik
Schmidt, Claudia
Muenzner, Julienne K.
Schobert, Rainer
Wölfl, Stefan
Ott, Ingo
author_facet Zhang, Jing‐Jing
Abu el Maaty, Mohamed A.
Hoffmeister, Henrik
Schmidt, Claudia
Muenzner, Julienne K.
Schobert, Rainer
Wölfl, Stefan
Ott, Ingo
author_sort Zhang, Jing‐Jing
collection PubMed
description A novel alkynyl phosphane gold(I) complex (trimethylphosphane)(3‐(1,3‐dimethylxanthine‐7‐yl)prop‐1‐yn‐1‐yl)gold(I) 1 displayed mutiple biological activites including selective proliferation inhibitory, anti‐metastatic, and anti‐angiogenic effects. The complex also induced effects related to aneuploidy in HCT‐116 colon carcinoma cells, which might be mainly ascribed to the dysfunction of mitochondrial bioenergetics and downregulation of glycolysis. Induction of aneuploidy beyond a critical level can provide an effective strategy to target cancer, in particular colorectal tumours with a low tolerance of aneuploidy, and could be of relevance for 1 and other metallodrugs.
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spelling pubmed-75400602020-10-09 A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells Zhang, Jing‐Jing Abu el Maaty, Mohamed A. Hoffmeister, Henrik Schmidt, Claudia Muenzner, Julienne K. Schobert, Rainer Wölfl, Stefan Ott, Ingo Angew Chem Int Ed Engl Research Articles A novel alkynyl phosphane gold(I) complex (trimethylphosphane)(3‐(1,3‐dimethylxanthine‐7‐yl)prop‐1‐yn‐1‐yl)gold(I) 1 displayed mutiple biological activites including selective proliferation inhibitory, anti‐metastatic, and anti‐angiogenic effects. The complex also induced effects related to aneuploidy in HCT‐116 colon carcinoma cells, which might be mainly ascribed to the dysfunction of mitochondrial bioenergetics and downregulation of glycolysis. Induction of aneuploidy beyond a critical level can provide an effective strategy to target cancer, in particular colorectal tumours with a low tolerance of aneuploidy, and could be of relevance for 1 and other metallodrugs. John Wiley and Sons Inc. 2020-07-30 2020-09-14 /pmc/articles/PMC7540060/ /pubmed/32529715 http://dx.doi.org/10.1002/anie.202006212 Text en © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Zhang, Jing‐Jing
Abu el Maaty, Mohamed A.
Hoffmeister, Henrik
Schmidt, Claudia
Muenzner, Julienne K.
Schobert, Rainer
Wölfl, Stefan
Ott, Ingo
A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells
title A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells
title_full A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells
title_fullStr A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells
title_full_unstemmed A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells
title_short A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells
title_sort multitarget gold(i) complex induces cytotoxicity related to aneuploidy in hct‐116 colorectal carcinoma cells
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540060/
https://www.ncbi.nlm.nih.gov/pubmed/32529715
http://dx.doi.org/10.1002/anie.202006212
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