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Quantitative analysis of 11‐dehydrocorticosterone and corticosterone for preclinical studies by liquid chromatography/triple quadrupole mass spectrometry
RATIONALE: The activity of the glucocorticoid activating enzyme 11β‐hydroxysteroid dehydrogenase type‐1 (11βHSD1) is altered in diseases such as obesity, inflammation and psychiatric disorders. In rodents 11βHSD1 converts inert 11‐dehydrocorticosterone (11‐DHC) into the active form, corticosterone (...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540072/ https://www.ncbi.nlm.nih.gov/pubmed/31677354 http://dx.doi.org/10.1002/rcm.8610 |