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Quantitative analysis of 11‐dehydrocorticosterone and corticosterone for preclinical studies by liquid chromatography/triple quadrupole mass spectrometry

RATIONALE: The activity of the glucocorticoid activating enzyme 11β‐hydroxysteroid dehydrogenase type‐1 (11βHSD1) is altered in diseases such as obesity, inflammation and psychiatric disorders. In rodents 11βHSD1 converts inert 11‐dehydrocorticosterone (11‐DHC) into the active form, corticosterone (...

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Verma, Manu, Sooy, Karen, Just, George, Nixon, Mark, Morgan, Ruth, Andrew, Ruth, Chapman, Karen E., Homer, Natalie Z.M.
Formáid: Online Alt Téacs
Teanga:English
Foilsithe / Cruthaithe: John Wiley and Sons Inc. 2020
Ábhair:
Rochtain ar líne:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540072/
https://www.ncbi.nlm.nih.gov/pubmed/31677354
http://dx.doi.org/10.1002/rcm.8610