Reactions in Tirapazamine Induced by the Attachment of Low‐Energy Electrons: Dissociation Versus Roaming of OH

Tirapazamine (TPZ) has been tested in clinical trials on radio‐chemotherapy due to its potential highly selective toxicity towards hypoxic tumor cells. It was suggested that either the hydroxyl radical or benzotriazinyl radical may form as bioactive radical after the initial reduction of TPZ in solu...

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Detalles Bibliográficos
Autores principales: Arthur‐Baidoo, Eugene, Ameixa, João, Ziegler, Patrick, Ferreira da Silva, Filipe, Ončák, Milan, Denifl, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540495/
https://www.ncbi.nlm.nih.gov/pubmed/32543771
http://dx.doi.org/10.1002/anie.202006675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540495/
https://www.ncbi.nlm.nih.gov/pubmed/32543771
http://dx.doi.org/10.1002/anie.202006675

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