Anti‐migraine Calcitonin Gene–Related Peptide Receptor Antagonists Worsen Cerebral Ischemic Outcome in Mice

OBJECTIVE: Calcitonin gene–related peptide (CGRP) pathway inhibitors are emerging treatments for migraine. CGRP‐mediated vasodilation is, however, a critical rescue mechanism in ischemia. We, therefore, investigated whether gepants, small molecule CGRP receptor antagonists, worsen cerebral ischemia....

Descripción completa

Detalles Bibliográficos
Autores principales: Mulder, Inge A., Li, Mei, de Vries, Tessa, Qin, Tao, Yanagisawa, Takeshi, Sugimoto, Kazutaka, van den Bogaerdt, Antoon, Danser, A. H. Jan, Wermer, Marieke J. H., van den Maagdenberg, Arn M. J. M., MaassenVanDenBrink, Antoinette, Ferrari, Michel D., Ayata, Cenk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540520/
https://www.ncbi.nlm.nih.gov/pubmed/32583883
http://dx.doi.org/10.1002/ana.25831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540520/
https://www.ncbi.nlm.nih.gov/pubmed/32583883
http://dx.doi.org/10.1002/ana.25831

Ejemplares similares