Ribosomal Target‐Binding Sites of Antimicrobial Peptides Api137 and Onc112 Are Conserved among Pathogens Indicating New Lead Structures To Develop Novel Broad‐Spectrum Antibiotics

Proline‐rich antimicrobial peptides expressed in insects are primarily active against Enterobacteriaceae. Mechanistically, they target the bacterial (70S) ribosome after partially transporter‐based cellular uptake, as revealed for Api137 and Onc112 on Escherichia coli. Following molecular modeling i...

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Detalles Bibliográficos
Autores principales: Kolano, Lisa, Knappe, Daniel, Volke, Daniela, Sträter, Norbert, Hoffmann, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540576/
https://www.ncbi.nlm.nih.gov/pubmed/32293093
http://dx.doi.org/10.1002/cbic.202000109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540576/
https://www.ncbi.nlm.nih.gov/pubmed/32293093
http://dx.doi.org/10.1002/cbic.202000109

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