An α2,3‐Sialyltransferase from Photobacterium phosphoreum with Broad Substrate Scope: Controlling Hydrolytic Activity by Directed Evolution

Defined sialoglycoconjugates are important molecular probes for studying the role of sialylated glycans in biological systems. We show that the α2,3‐sialyltransferase from Photobacterium phosphoreum JT‐ISH‐467 (2,3SiaT(pph)) tolerates a very broad substrate scope for modifications in the sialic acid...

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Detalles Bibliográficos
Autores principales: Mertsch, Alexander, He, Ning, Yi, Dong, Kickstein, Michael, Fessner, Wolf‐Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540698/
https://www.ncbi.nlm.nih.gov/pubmed/32596832
http://dx.doi.org/10.1002/chem.202002277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540698/
https://www.ncbi.nlm.nih.gov/pubmed/32596832
http://dx.doi.org/10.1002/chem.202002277

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