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An α2,3‐Sialyltransferase from Photobacterium phosphoreum with Broad Substrate Scope: Controlling Hydrolytic Activity by Directed Evolution
Defined sialoglycoconjugates are important molecular probes for studying the role of sialylated glycans in biological systems. We show that the α2,3‐sialyltransferase from Photobacterium phosphoreum JT‐ISH‐467 (2,3SiaT(pph)) tolerates a very broad substrate scope for modifications in the sialic acid...
Autores principales: | Mertsch, Alexander, He, Ning, Yi, Dong, Kickstein, Michael, Fessner, Wolf‐Dieter |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540698/ https://www.ncbi.nlm.nih.gov/pubmed/32596832 http://dx.doi.org/10.1002/chem.202002277 |
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