Bacterial metabolism of bile acids promotes peripheral Treg cell generation

Intestinal health relies on the immunosuppressive activity of CD4(+) regulatory T (Treg) cells(1). Foxp3 expression defines this lineage and can be induced extrathymically by dietary or commensal-derived antigens in a process assisted by the Foxp3 enhancer CNS1 (conserved non-coding sequence 1)(2–4)...

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Detalles Bibliográficos
Autores principales: Campbell, Clarissa, McKenney, Peter T., Konstantinovsky, Daniel, Isaeva, Olga I., Schizas, Michael, Verter, Jacob, Mai, Cheryl, Jin, Wen-Bing, Guo, Chun-Jun, Violante, Sara, Ramos, Ruben J., Cross, Justin R., Kadaveru, Krishna, Hambor, John, Rudensky, Alexander Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540721/
https://www.ncbi.nlm.nih.gov/pubmed/32461639
http://dx.doi.org/10.1038/s41586-020-2193-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540721/
https://www.ncbi.nlm.nih.gov/pubmed/32461639
http://dx.doi.org/10.1038/s41586-020-2193-0

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