TGFβ1 Induces Axonal Outgrowth via ALK5/PKA/SMURF1-Mediated Degradation of RhoA and Stabilization of PAR6

Transforming growth factor (TGF)β1 has repeatedly been associated with axonal regeneration and recovery after injury to the CNS. We found TGFβ1 upregulated in the stroke-denervated mouse spinal cord after ischemic injury to the motor cortex as early as 4 d postinjury (dpi) and persisting up to 28 dp...

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Detalles Bibliográficos
Autores principales: Kaiser, Julia, Maibach, Martina, Piovesana, Ester, Salpeter, Iris, Escher, Nora, Ormen, Yannick, Schwab, Martin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2020
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540929/
https://www.ncbi.nlm.nih.gov/pubmed/32887692
http://dx.doi.org/10.1523/ENEURO.0104-20.2020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540929/
https://www.ncbi.nlm.nih.gov/pubmed/32887692
http://dx.doi.org/10.1523/ENEURO.0104-20.2020

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