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Solution NMR readily reveals distinct structural folds and interactions in doubly (13)C- and (19)F-labeled RNAs

RNAs form critical components of biological processes implicated in human diseases, making them attractive for small-molecule therapeutics. Expanding the sites accessible to nuclear magnetic resonance (NMR) spectroscopy will provide atomic-level insights into RNA interactions. Here, we present an ef...

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Detalles Bibliográficos
Autores principales: Becette, Owen B., Zong, Guanghui, Chen, Bin, Taiwo, Kehinde M., Case, David A., Dayie, T. Kwaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541061/
https://www.ncbi.nlm.nih.gov/pubmed/33028531
http://dx.doi.org/10.1126/sciadv.abc6572