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Solution NMR readily reveals distinct structural folds and interactions in doubly (13)C- and (19)F-labeled RNAs
RNAs form critical components of biological processes implicated in human diseases, making them attractive for small-molecule therapeutics. Expanding the sites accessible to nuclear magnetic resonance (NMR) spectroscopy will provide atomic-level insights into RNA interactions. Here, we present an ef...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541061/ https://www.ncbi.nlm.nih.gov/pubmed/33028531 http://dx.doi.org/10.1126/sciadv.abc6572 |