PTPRG is an ischemia risk locus essential for HCO(3)(–)-dependent regulation of endothelial function and tissue perfusion

Acid-base conditions modify artery tone and tissue perfusion but the involved vascular-sensing mechanisms and disease consequences remain unclear. We experimentally investigated transgenic mice and performed genetic studies in a UK-based human cohort. We show that endothelial cells express the putat...

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Detalles Bibliográficos
Autores principales: Hansen, Kristoffer B, Staehr, Christian, Rohde, Palle D, Homilius, Casper, Kim, Sukhan, Nyegaard, Mette, Matchkov, Vladimir V, Boedtkjer, Ebbe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541084/
https://www.ncbi.nlm.nih.gov/pubmed/32955439
http://dx.doi.org/10.7554/eLife.57553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541084/
https://www.ncbi.nlm.nih.gov/pubmed/32955439
http://dx.doi.org/10.7554/eLife.57553

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