Inhibition of ER stress improves progressive motor deficits in a REEP1-null mouse model of hereditary spastic paraplegia

Hereditary spastic paraplegias (HSPs) are genetic neurodegenerative diseases. HSPs are characterized by lower-extremity weakness and spasticity. However, there is no specific clinical treatment strategy to prevent or reverse nerve degeneration in HSPs. Mutations in receptor expression-enhancing prot...

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Detalles Bibliográficos
Autores principales: Wang, Bingjie, Yu, You, Wei, Lai, Zhang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541344/
https://www.ncbi.nlm.nih.gov/pubmed/32878877
http://dx.doi.org/10.1242/bio.054296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541344/
https://www.ncbi.nlm.nih.gov/pubmed/32878877
http://dx.doi.org/10.1242/bio.054296

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