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Analyzing the M. tuberculosis immune response by T cell receptor clustering with GLIPH2 and genome-wide antigen screening
CD4(+) T cells are critical to fighting pathogens, but a comprehensive analysis of human T cell specificities is hindered by the diversity of HLA alleles (>20,000) and the complexity of many pathogen genomes. We previously described GLIPH, an algorithm to cluster T cell receptors (TCRs) that reco...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541396/ https://www.ncbi.nlm.nih.gov/pubmed/32341563 http://dx.doi.org/10.1038/s41587-020-0505-4 |