Nesfatin-1 and nesfatin-1-like peptide suppress growth hormone synthesis via the AC/PKA/CREB pathway in mammalian somatotrophs

Nesfatin-1 (NESF) and NESF-like peptide (NLP), encoded in nucleobindin 2 and 1 (NUCB2 and NUCB1), respectively, are orphan ligands and metabolic factors. We hypothesized that NESF and NLP suppress growth hormone (GH) synthesis, and aimed to determine whether mammalian somatotrophs are a source and s...

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Detalles Bibliográficos
Autores principales: Vélez, Emilio J., Unniappan, Suraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541516/
https://www.ncbi.nlm.nih.gov/pubmed/33028951
http://dx.doi.org/10.1038/s41598-020-73840-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541516/
https://www.ncbi.nlm.nih.gov/pubmed/33028951
http://dx.doi.org/10.1038/s41598-020-73840-4

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