Transcription imparts architecture, function, and logic to enhancer units

Distal enhancers play pivotal roles in development and disease yet remain one of the least understood regulatory elements. We used massively parallel reporter assays to perform functional comparisons of two leading enhancer models and find that gene-distal transcription start sites (TSSs) are robust...

Descripción completa

Detalles Bibliográficos
Autores principales: Tippens, Nathaniel D., Liang, Jin, King-Yung Leung, Alden, Wierbowski, Shayne D., Ozer, Abdullah, Booth, James G., Lis, John T., Yu, Haiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541647/
https://www.ncbi.nlm.nih.gov/pubmed/32958950
http://dx.doi.org/10.1038/s41588-020-0686-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541647/
https://www.ncbi.nlm.nih.gov/pubmed/32958950
http://dx.doi.org/10.1038/s41588-020-0686-2

Ejemplares similares