Comparison of CYP2C9 Activity in Ethiopian and Non-Ethiopian Jews Using Phenytoin as a Probe

The pharmacokinetics of CYP2C9 substrates is characterized by substantial interethnic variability. The objective of the study was to compare CYP2C9 activity by using Phenytoin Metabolic Ratio (PMR) between Ethiopian and non-Ethiopian Jews. PMR was derived from the ratio of p-HPPH in 24 h urine colle...

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Detalles Bibliográficos
Autores principales: Abu Ghosh, Zahi, Alamia, Shoshana, Shaul, Chanan, Caraco, Yoseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542311/
https://www.ncbi.nlm.nih.gov/pubmed/33071782
http://dx.doi.org/10.3389/fphar.2020.566842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542311/
https://www.ncbi.nlm.nih.gov/pubmed/33071782
http://dx.doi.org/10.3389/fphar.2020.566842

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