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Quantifying the Role of Lysine in Prion Replication by Nano-LC Mass Spectrometry and Bioassay
Prions propagate by a template driven process, inducing the normal cellular isoform (PrP(C)) to adopt the prion (PrP(Sc)) conformation. In PrP(C), the positions of lysines are highly conserved and strongly influence prion propagation. In this study, covalent modification was used to quantitate the r...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542330/ https://www.ncbi.nlm.nih.gov/pubmed/33072723 http://dx.doi.org/10.3389/fbioe.2020.562953 |