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Quantifying the Role of Lysine in Prion Replication by Nano-LC Mass Spectrometry and Bioassay

Prions propagate by a template driven process, inducing the normal cellular isoform (PrP(C)) to adopt the prion (PrP(Sc)) conformation. In PrP(C), the positions of lysines are highly conserved and strongly influence prion propagation. In this study, covalent modification was used to quantitate the r...

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Detalles Bibliográficos
Autores principales:	Silva, Christopher J., Erickson-Beltran, Melissa L., Dynin, Irina C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542330/ https://www.ncbi.nlm.nih.gov/pubmed/33072723 http://dx.doi.org/10.3389/fbioe.2020.562953

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