Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus

Here, we investigate a monoclonal antibody, Z2B3, isolated from an H7N9-infected patient, that exhibited cross-reactivity to both N9 (group 2) and a broad range of seasonal and avian N1 (group 1) proteins but lost activity to the N1 with the substitution K432E. This substitution exists in 99.25% of...

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Detalles Bibliográficos
Autores principales: Jiang, Haihai, Peng, Weiyu, Qi, Jianxun, Chai, Yan, Song, Hao, Bi, Yuhai, Rijal, Pramila, Wang, Haiyuan, Oladejo, Babayemi O., Liu, Jinhua, Shi, Yi, Gao, George F., Townsend, Alain R., Wu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542365/
https://www.ncbi.nlm.nih.gov/pubmed/33024040
http://dx.doi.org/10.1128/mBio.02315-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542365/
https://www.ncbi.nlm.nih.gov/pubmed/33024040
http://dx.doi.org/10.1128/mBio.02315-20

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