Overexpression of Cyclin E1 or Cdc25A leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors

Oncogene-induced replication stress, for instance as a result of Cyclin E1 overexpression, causes genomic instability and has been linked to tumorigenesis. To survive high levels of replication stress, tumors depend on pathways to deal with these DNA lesions, which represent a therapeutically action...

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Detalles Bibliográficos
Autores principales: Kok, Yannick P., Guerrero Llobet, Sergi, Schoonen, Pepijn M., Everts, Marieke, Bhattacharya, Arkajyoti, Fehrmann, Rudolf S. N., van den Tempel, Nathalie, van Vugt, Marcel A. T. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542455/
https://www.ncbi.nlm.nih.gov/pubmed/33028815
http://dx.doi.org/10.1038/s41389-020-00270-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542455/
https://www.ncbi.nlm.nih.gov/pubmed/33028815
http://dx.doi.org/10.1038/s41389-020-00270-2

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