Cargando…

GDF15 Repression Contributes to 5-Fluorouracil Resistance in Human Colon Cancer by Regulating Epithelial-Mesenchymal Transition and Apoptosis

Chemotherapy based on 5-fluorouracil (5-FU) is the standard approach for colon cancer treatment, and resistance to 5-FU is a significant obstacle in the clinical treatment of colon cancer. However, the mechanisms underlying 5-FU resistance in colon cancer cells remain largely unknown. This study aim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Bin, Ma, Nina, Zheng, Xixi, Li, Xiao, Ma, Xiao, Hu, Jiexuan, Cao, Bangwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542494/ https://www.ncbi.nlm.nih.gov/pubmed/33062674 http://dx.doi.org/10.1155/2020/2826010

Ejemplares similares

Exosomes derived from 5-fluorouracil-resistant colon cancer cells are enriched in GDF15 and can promote angiogenesis
por: Zheng, Xixi, et al.
Publicado: (2020)

IL-17A and GDF15 are able to induce epithelial-mesenchymal transition of lung epithelial cells in response to cigarette smoke
por: Jiang, Gang, et al.
Publicado: (2018)

LRG1 Suppresses Migration and Invasion of Esophageal Squamous Cell Carcinoma by Modulating Epithelial to Mesenchymal Transition
por: Zhang, Ninggang, et al.
Publicado: (2020)

GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis
por: Zhang, Yingze, et al.
Publicado: (2019)

A GDF15 3′ UTR variant, rs1054564, results in allele-specific translational repression of GDF15 by hsa-miR-1233-3p
por: Teng, Ming-Sheng, et al.
Publicado: (2017)

GDF15 and Growth Control
por: Emmerson, Paul J., et al.
Publicado: (2018)

Ginseng-derived nanoparticles inhibit lung cancer cell epithelial mesenchymal transition by repressing pentose phosphate pathway activity
por: Yang, Lan, et al.
Publicado: (2022)

The ELF3 transcription factor is associated with an epithelial phenotype and represses epithelial-mesenchymal transition
por: Subbalakshmi, Ayalur Raghu, et al.
Publicado: (2023)

Repression of Smad3 by silencing Robo1 attenuates epithelial-mesenchymal transition in tracheobronchial stenosis
por: He, Chunyan, et al.
Publicado: (2023)

GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21
por: Wang, Di-Xian, et al.
Publicado: (2023)

GDF10 inhibits proliferation and epithelial-mesenchymal transition in triple‐negative breast cancer via upregulation of Smad7
por: Zhou, Tian, et al.
Publicado: (2019)

Risk of Cardiac Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-Analysis
por: Hu, Jiexuan, et al.
Publicado: (2021)

DUOX2-mediated production of reactive oxygen species induces epithelial mesenchymal transition in 5-fluorouracil resistant human colon cancer cells
por: Kang, Kyoung Ah, et al.
Publicado: (2018)

Anti-metastatic effect of metformin via repression of interleukin 6-induced epithelial–mesenchymal transition in human colon cancer cells
por: Kang, Sanghee, et al.
Publicado: (2018)

The Role of GDF15 as a Myomitokine
por: Johann, Kornelia, et al.
Publicado: (2021)

Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy
por: Fejzo, M, et al.
Publicado: (2023)

Nuclear factor I/B promotes colorectal cancer cell proliferation, epithelial‐mesenchymal transition and 5‐fluorouracil resistance
por: Liu, ZhengYi, et al.
Publicado: (2018)

CXXC4 activates apoptosis through up-regulating GDF15 in gastric cancer
por: Han, Mengjiao, et al.
Publicado: (2017)

SLC27A2 mediates FAO in colorectal cancer through nongenic crosstalk regulation of the PPARs pathway
por: Shang, Kun, et al.
Publicado: (2023)

JunB contributes to Id2 repression and the epithelial–mesenchymal transition in response to transforming growth factor–β
por: Gervasi, Megan, et al.
Publicado: (2012)

Cortactin in Epithelial–Mesenchymal Transition
por: Ji, Rong, et al.
Publicado: (2020)

Atypical role of sprouty in colorectal cancer: sprouty repression inhibits epithelial–mesenchymal transition
por: Zhang, Q, et al.
Publicado: (2016)

ACTL6A expression promotes invasion, metastasis and epithelial mesenchymal transition of colon cancer
por: Zeng, Zhijun, et al.
Publicado: (2018)

Exercise increases circulating GDF15 in humans
por: Kleinert, Maximilian, et al.
Publicado: (2018)

Epithelial cell-derived cytokines CST3 and GDF15 as potential therapeutics for pulmonary fibrosis
por: Kim, Young-Im, et al.
Publicado: (2018)

SCAP Mediated GDF15-Induced Invasion and EMT of Esophageal Cancer
por: Dong, Gang, et al.
Publicado: (2020)

Inhibition of Ribosomal RNA Processing 15 Homolog (RRP15) Suppressed Tumor Growth, Invasion and Epithelial to Mesenchymal Transition (EMT) of Colon Cancer
por: Deng, Zirong, et al.
Publicado: (2023)

MicroRNA-26a suppresses epithelial-mesenchymal transition in human hepatocellular carcinoma by repressing enhancer of zeste homolog 2
por: Ma, De-Ning, et al.
Publicado: (2016)

Overexpression of PPT2 Represses the Clear Cell Renal Cell Carcinoma Progression by Reducing Epithelial-to-mesenchymal Transition
por: Yuan, ChangFei, et al.
Publicado: (2020)

Camptothecin effectively treats obesity in mice through GDF15 induction
por: Lu, Jun Feng, et al.
Publicado: (2022)

Senescence‐associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15
por: Guo, Yuna, et al.
Publicado: (2019)

MSI2 knockdown represses extrahepatic cholangiocarcinoma growth and invasion by inhibiting epithelial–mesenchymal transition
por: Hu, Feihu, et al.
Publicado: (2018)

Erratum: Atypical role of sprouty in colorectal cancer: sprouty repression inhibits epithelial–mesenchymal transition
por: Zhang, Q, et al.
Publicado: (2017)

β-Patchoulene represses hypoxia-induced proliferation and epithelial-mesenchymal transition of liver cancer cells
por: Tu, Huahua, et al.
Publicado: (2022)

DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy
por: Dardare, Julie, et al.
Publicado: (2022)

Increased expression and accumulation of GDF15 in IPF extracellular matrix contribute to fibrosis
por: Radwanska, Agata, et al.
Publicado: (2022)

GDF15 Contributes to Radioresistance by Mediating the EMT and Stemness of Breast Cancer Cells
por: Zhao, Xinrui, et al.
Publicado: (2022)

Angiogenesis enhanced by treatment damage to hepatocellular carcinoma through the release of GDF15
por: Dong, Gang, et al.
Publicado: (2018)

Salinomycin repressed the epithelial–mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt/β-catenin pathway
por: Li, Rui, et al.
Publicado: (2017)

Natural Compound Shikonin Induces Apoptosis and Attenuates Epithelial to Mesenchymal Transition in Radiation-Resistant Human Colon Cancer Cells
por: Shilnikova, Kristina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_arvudcogpsmhf27ucekrlpmbh7