Overexpression of Slit2 decreases neuronal excitotoxicity, accelerates glymphatic clearance, and improves cognition in a multiple microinfarcts model

BACKGROUND: Cerebral microinfarcts (MIs) lead to progressive cognitive impairments in the elderly, and there is currently no effective preventative strategy due to uncertainty about the underlying pathogenic mechanisms. One possibility is the dysfunction of GABAergic transmission and ensuing excitot...

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Detalles Bibliográficos
Autores principales: He, Xiao-fei, Li, Ge, Li, Li-li, Li, Ming-yue, Liang, Feng-yin, Chen, Xi, Hu, Xi-quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542754/
https://www.ncbi.nlm.nih.gov/pubmed/33028376
http://dx.doi.org/10.1186/s13041-020-00659-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542754/
https://www.ncbi.nlm.nih.gov/pubmed/33028376
http://dx.doi.org/10.1186/s13041-020-00659-5

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