Nuclear body phase separation drives telomere clustering in ALT cancer cells

Telomerase-free cancer cells employ a recombination-based alternative lengthening of telomeres (ALT) pathway that depends on ALT-associated promyelocytic leukemia nuclear bodies (APBs), whose function is unclear. We find that APBs behave as liquid condensates in response to telomere DNA damage, sugg...

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Detalles Bibliográficos
Autores principales: Zhang, Huaiying, Zhao, Rongwei, Tones, Jason, Liu, Michel, Dilley, Robert L., Chenoweth, David M., Greenberg, Roger A., Lampson, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543070/
https://www.ncbi.nlm.nih.gov/pubmed/32579423
http://dx.doi.org/10.1091/mbc.E19-10-0589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543070/
https://www.ncbi.nlm.nih.gov/pubmed/32579423
http://dx.doi.org/10.1091/mbc.E19-10-0589

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