The N-terminal length and side-chain composition of CXCL13 affect crystallization, structure and functional activity

CXCL13 is the cognate chemokine agonist of CXCR5, a class A G-protein-coupled receptor (GPCR) that is essential for proper humoral immune responses. Using a ‘methionine scanning’ mutagenesis method on the N-terminus of CXCL13, which is the chemokine signaling region, it was shown that minor length a...

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Detalles Bibliográficos
Autores principales: Rosenberg, Eric M., Herrington, James, Rajasekaran, Deepa, Murphy, James W., Pantouris, Georgios, Lolis, Elias J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2020
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543660/
https://www.ncbi.nlm.nih.gov/pubmed/33021505
http://dx.doi.org/10.1107/S2059798320011687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543660/
https://www.ncbi.nlm.nih.gov/pubmed/33021505
http://dx.doi.org/10.1107/S2059798320011687

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