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Inhibition of overexpressed Kv3.4 augments HPV in endotoxemic mice

BACKGROUND: Hypoxic pulmonary vasoconstriction (HPV) is a reaction of the pulmonary vasculature upon hypoxia, diverting blood flow into ventilated areas to preserve oxygenation. It is impaired in endotoxemia or ARDS. Voltage gated potassium channels have been shown to play a key role in the regulati...

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Detalles Bibliográficos
Autores principales: Turzo, Maurizio, Metzger, Karin, Lasitschka, Felix, Weigand, Markus A., Busch, Cornelius J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543677/
https://www.ncbi.nlm.nih.gov/pubmed/33032555
http://dx.doi.org/10.1186/s12890-020-01278-5