Divergent synthesis of a thiolate-based α-hydroxytropolone library with a dynamic bioactivity profile

Here we describe a rapid and divergent synthetic route toward structurally novel αHTs functionalized with either one or two thioether or sulfonyl appendages. Evaluation of this library against hepatitis B and herpes simplex virus, as well as the pathogenic fungus Cryptococcus neoformans, revealed co...

Descripción completa

Detalles Bibliográficos
Autores principales: Agyemang, Nana B., Kukla, Cassandra R., Edwards, Tiffany C., Li, Qilan, Langen, Madison K., Schaal, Alexandra, Franson, Abaigeal D., Casals, Andreu Gazquez, Donald, Katherine A., Yu, Alice J., Donlin, Maureen J., Morrison, Lynda A., Tavis, John E., Murelli, Ryan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543996/
https://www.ncbi.nlm.nih.gov/pubmed/33042521
http://dx.doi.org/10.1039/c9ra06383h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543996/
https://www.ncbi.nlm.nih.gov/pubmed/33042521
http://dx.doi.org/10.1039/c9ra06383h

Ejemplares similares