Modeling the efficiency of filovirus entry into cells in vitro: Effects of SNP mutations in the receptor molecule

Interaction between filovirus glycoprotein (GP) and the Niemann-Pick C1 (NPC1) protein is essential for membrane fusion during virus entry. Some single-nucleotide polymorphism (SNPs) in two surface-exposed loops of NPC1 are known to reduce viral infectivity. However, the dependence of differences in...

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Detalles Bibliográficos
Autores principales: Kim, Kwang Su, Kondoh, Tatsunari, Asai, Yusuke, Takada, Ayato, Iwami, Shingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544041/
https://www.ncbi.nlm.nih.gov/pubmed/32986692
http://dx.doi.org/10.1371/journal.pcbi.1007612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544041/
https://www.ncbi.nlm.nih.gov/pubmed/32986692
http://dx.doi.org/10.1371/journal.pcbi.1007612

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