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Modeling the efficiency of filovirus entry into cells in vitro: Effects of SNP mutations in the receptor molecule
Interaction between filovirus glycoprotein (GP) and the Niemann-Pick C1 (NPC1) protein is essential for membrane fusion during virus entry. Some single-nucleotide polymorphism (SNPs) in two surface-exposed loops of NPC1 are known to reduce viral infectivity. However, the dependence of differences in...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544041/ https://www.ncbi.nlm.nih.gov/pubmed/32986692 http://dx.doi.org/10.1371/journal.pcbi.1007612 |