A redox switch regulates the structure and function of anti-apoptotic BFL-1

Apoptosis is regulated by BCL-2 family proteins. Anti-apoptotic members suppress cell death by deploying a surface groove to capture the critical BH3 α-helix of pro-apoptotic members. Cancer cells hijack this mechanism by overexpressing anti-apoptotic BCL-2 family proteins to enforce cellular immort...

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Detalles Bibliográficos
Autores principales: Korshavn, Kyle J., Wales, Thomas E., Bird, Gregory H., Engen, John R., Walensky, Loren D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544158/
https://www.ncbi.nlm.nih.gov/pubmed/32661419
http://dx.doi.org/10.1038/s41594-020-0458-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544158/
https://www.ncbi.nlm.nih.gov/pubmed/32661419
http://dx.doi.org/10.1038/s41594-020-0458-9

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