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A redox switch regulates the structure and function of anti-apoptotic BFL-1

Apoptosis is regulated by BCL-2 family proteins. Anti-apoptotic members suppress cell death by deploying a surface groove to capture the critical BH3 α-helix of pro-apoptotic members. Cancer cells hijack this mechanism by overexpressing anti-apoptotic BCL-2 family proteins to enforce cellular immort...

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Detalles Bibliográficos
Autores principales:	Korshavn, Kyle J., Wales, Thomas E., Bird, Gregory H., Engen, John R., Walensky, Loren D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544158/ https://www.ncbi.nlm.nih.gov/pubmed/32661419 http://dx.doi.org/10.1038/s41594-020-0458-9

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