Readthrough of stop codons under limiting ABCE1 concentration involves frameshifting and inhibits nonsense-mediated mRNA decay

To gain insight into the mechanistic link between translation termination and nonsense-mediated mRNA decay (NMD), we depleted the ribosome recycling factor ABCE1 in human cells, resulting in an upregulation of NMD-sensitive mRNAs. Suppression of NMD on these mRNAs occurs prior to their SMG6-mediated...

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Detalles Bibliográficos
Autores principales: Annibaldis, Giuditta, Domanski, Michal, Dreos, René, Contu, Lara, Carl, Sarah, Kläy, Nina, Mühlemann, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544199/
https://www.ncbi.nlm.nih.gov/pubmed/32941650
http://dx.doi.org/10.1093/nar/gkaa758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544199/
https://www.ncbi.nlm.nih.gov/pubmed/32941650
http://dx.doi.org/10.1093/nar/gkaa758

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