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Readthrough of stop codons under limiting ABCE1 concentration involves frameshifting and inhibits nonsense-mediated mRNA decay
To gain insight into the mechanistic link between translation termination and nonsense-mediated mRNA decay (NMD), we depleted the ribosome recycling factor ABCE1 in human cells, resulting in an upregulation of NMD-sensitive mRNAs. Suppression of NMD on these mRNAs occurs prior to their SMG6-mediated...
Autores principales: | Annibaldis, Giuditta, Domanski, Michal, Dreos, René, Contu, Lara, Carl, Sarah, Kläy, Nina, Mühlemann, Oliver |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544199/ https://www.ncbi.nlm.nih.gov/pubmed/32941650 http://dx.doi.org/10.1093/nar/gkaa758 |
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