Weak binding to the A2RE RNA rigidifies hnRNPA2 RRMs and reduces liquid–liquid phase separation and aggregation

hnRNPA2 is a major component of mRNA transport granules in oligodendrocytes and neurons. However, the structural details of how hnRNPA2 binds the A2 recognition element (A2RE) and if this sequence stimulates granule formation by enhancing phase separation of hnRNPA2 has not yet been studied. Using s...

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Detalles Bibliográficos
Autores principales: Ryan, Veronica H, Watters, Scott, Amaya, Joshua, Khatiwada, Balabhadra, Venditti, Vincenzo, Naik, Mandar T, Fawzi, Nicolas L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544213/
https://www.ncbi.nlm.nih.gov/pubmed/32870271
http://dx.doi.org/10.1093/nar/gkaa710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544213/
https://www.ncbi.nlm.nih.gov/pubmed/32870271
http://dx.doi.org/10.1093/nar/gkaa710

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