Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5′-(R)- and 5′-(S)-C-methyl-guanosine

Various chemical modifications have been identified that enhance potency of small interfering RNAs (siRNAs) and that reduce off-target effects, immune stimulation, and toxicities of metabolites of these therapeutic agents. We previously described 5′-C-methyl pyrimidine nucleotides also modified at t...

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Detalles Bibliográficos
Autores principales: Mikami, Atsushi, Erande, Namrata, Matsuda, Shigeo, Kel’in, Alexander, Woods, Lauren Blair, Chickering, Tyler, Pallan, Pradeep S, Schlegel, Mark K, Zlatev, Ivan, Egli, Martin, Manoharan, Muthiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544225/
https://www.ncbi.nlm.nih.gov/pubmed/32990754
http://dx.doi.org/10.1093/nar/gkaa750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544225/
https://www.ncbi.nlm.nih.gov/pubmed/32990754
http://dx.doi.org/10.1093/nar/gkaa750

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