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Locked nucleic acid building blocks as versatile tools for advanced G-quadruplex design
A hybrid-type G-quadruplex is modified with LNA (locked nucleic acid) and 2′-F-riboguanosine in various combinations at the two syn positions of its third antiparallel G-tract. LNA substitution in the central tetrad causes a complete rearrangement to either a V-loop or antiparallel structure, depend...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544228/ https://www.ncbi.nlm.nih.gov/pubmed/32890406 http://dx.doi.org/10.1093/nar/gkaa720 |