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Locked nucleic acid building blocks as versatile tools for advanced G-quadruplex design
A hybrid-type G-quadruplex is modified with LNA (locked nucleic acid) and 2′-F-riboguanosine in various combinations at the two syn positions of its third antiparallel G-tract. LNA substitution in the central tetrad causes a complete rearrangement to either a V-loop or antiparallel structure, depend...
Autores principales: | Haase, Linn, Weisz, Klaus |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544228/ https://www.ncbi.nlm.nih.gov/pubmed/32890406 http://dx.doi.org/10.1093/nar/gkaa720 |
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