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Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to oesophageal adenocarcinoma

Oesophageal adenocarcinoma (OAC) is one of the most common causes of cancer deaths. Barrett’s oesophagus (BO) is the only known precancerous precursor to OAC, but our understanding about the molecular events leading to OAC development is limited. Here, we have integrated gene expression and chromati...

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Detalles Bibliográficos
Autores principales: Rogerson, Connor, Ogden, Samuel, Britton, Edward, Ang, Yeng, Sharrocks, Andrew D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544504/
https://www.ncbi.nlm.nih.gov/pubmed/32880368
http://dx.doi.org/10.7554/eLife.57189