Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a(1798insD/+) mice

AIMS: SCN5A mutations are associated with arrhythmia syndromes, including Brugada syndrome, long QT syndrome type 3 (LQT3), and cardiac conduction disease. Long QT syndrome type 3 patients display atrio-ventricular (AV) conduction slowing which may contribute to arrhythmogenesis. We here investigate...

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Detalles Bibliográficos
Autores principales: Rivaud, Mathilde R, Marchal, Gerard A, Wolswinkel, Rianne, Jansen, John A, van der Made, Ingeborg, Beekman, Leander, Ruiz-Villalba, Adrián, Baartscheer, Antonius, Rajamani, Sridharan, Belardinelli, Luiz, van Veen, Toon A B, Basso, Cristina, Thiene, Gaetano, Creemers, Esther E, Bezzina, Connie R, Remme, Carol Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544532/
https://www.ncbi.nlm.nih.gov/pubmed/32778883
http://dx.doi.org/10.1093/europace/euaa127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544532/
https://www.ncbi.nlm.nih.gov/pubmed/32778883
http://dx.doi.org/10.1093/europace/euaa127

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