Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4

DNA methylation is implicated in the acquisition of malignant phenotypes, and the use of epigenetic modulating drugs is a promising anti-cancer therapeutic strategy. 5-aza-2’deoxycytidine (decitabine, 5-azadC) is an FDA-approved DNA methyltransferase (DNMT) inhibitor with proven effectiveness agains...

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Detalles Bibliográficos
Autores principales: Vernier, Mathieu, McGuirk, Shawn, Dufour, Catherine R., Wan, Liangxinyi, Audet-Walsh, Etienne, St-Pierre, Julie, Giguère, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544553/
https://www.ncbi.nlm.nih.gov/pubmed/32855526
http://dx.doi.org/10.1038/s41388-020-01438-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544553/
https://www.ncbi.nlm.nih.gov/pubmed/32855526
http://dx.doi.org/10.1038/s41388-020-01438-1

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