An aberrant STAT pathway is central to COVID-19

COVID-19 is caused by SARS-CoV-2 infection and characterized by diverse clinical symptoms. Type I interferon (IFN-I) production is impaired and severe cases lead to ARDS and widespread coagulopathy. We propose that COVID-19 pathophysiology is initiated by SARS-CoV-2 gene products, the NSP1 and ORF6...

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Detalles Bibliográficos
Autores principales: Matsuyama, Toshifumi, Kubli, Shawn P., Yoshinaga, Steven K., Pfeffer, Klaus, Mak, Tak W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545020/
https://www.ncbi.nlm.nih.gov/pubmed/33037393
http://dx.doi.org/10.1038/s41418-020-00633-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545020/
https://www.ncbi.nlm.nih.gov/pubmed/33037393
http://dx.doi.org/10.1038/s41418-020-00633-7

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