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Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle

Brain cells continuously produce and release protons into the extracellular space, with the rate of acid production corresponding to the levels of neuronal activity and metabolism. Efficient buffering and removal of excess H(+) is essential for brain function, not least because all the electrogenic...

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Detalles Bibliográficos
Autores principales: Theparambil, Shefeeq M., Hosford, Patrick S., Ruminot, Iván, Kopach, Olga, Reynolds, James R., Sandoval, Pamela Y., Rusakov, Dmitri A., Barros, L. Felipe, Gourine, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545092/
https://www.ncbi.nlm.nih.gov/pubmed/33033238
http://dx.doi.org/10.1038/s41467-020-18756-3